Alomari EB, et al. - In this randomized, split-mouth clinical trial, 18 subjects of age 12–16 years, with a skeletal maxillary constriction were examined to study the efficacy of platelet-rich plasma (PRP) with its growth factors in minimizing the adverse events due to rapid maxillary expansion (RME) on the periodontal tissue of anchoring teeth. The candidates were categorized as intervention and control sides. They estimated the buccal bone plate thickness (BBPT) and buccal bone crest level (BBCL) of anchoring teeth with high-resolution cone-beam computed tomography (CBCT) imaging (H-CBCT) carried out preoperatively (T0) and 3 months after retention (T1). No significant difference was reported in BBPT and BBCL between the 2 groups after RME. They found an increased prevalence of dehiscence and fenestrations was at (T1) in both groups whereas the percentage was higher in the PRP group. Conclusively, they suggested the induction of vertical and horizontal bone loss due to RME.