Abd Elazim NE, Abdelsalam AM, Awad SM, et al. - Findings demonstrate effectiveness as well as good tolerability of fractional CO ₂ laser as a treatment option for nail psoriasis; it affords improvement in the outcomes of topical tazarotene particularly in nail bed lesions.

• This study involved 27 patients with bilateral fingernail psoriasis who were treated with fractional carbon dioxide laser (FCL) plus topical tazarotene or tazarotene monotherapy.

• Both regimens resulted in significant improvements in the total, nail matrix, and nail bed modified Nail Psoriasis Severity Index scores at 3 and 6 months, but FCL/tazarotene combination caused greater reduction.

• Combination therapy provided faster improvement of nail matrix signs and greater efficacy for nail bed signs.

• More effectiveness in improving the dermoscopic nail bed features was shown by the combined therapy.

• With combined therapy, significantly higher patient's global assessment scores were obtained.

• Good tolerability was demonstrated by both treatments.