Rechmann P, et al. - Since adenosine triphosphate bioluminescence (ATP-B) readings were proposed as markers of caries risk, researchers ascertained if readings using a commercial ATP meter (CariScreen Testing Meter, Oral BioTech) were significantly different for patients with low, moderate, and high caries risk in the Caries Management by Risk Assessment Practice-Based Research Network study. Twenty practice-based research network dentists enlisted 460 individuals; 271 returned for 2 or more semiannual follow-up visits over 2 years. According to results, median ATP-B readings were not statistically significantly different at the level of risk of caries assessed by clinicians. Adjusted for patient demographics and trial intervention assignment, higher readings were not correlated with newly developed decayed, missing, or restored tooth surface or disease indicators at the following visit, whereas the level of risk of caries assessed by clinicians was strongly linked. Overall, the authors concluded that caries risk and future clinical results were poorly anticipated by ATP-B readings. Caries risk assessment has superior predictive performance that incorporates multiple indicators of risk, protective, and disease.