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Efficacy of a cell-culture–derived quadrivalent influenza vaccine in children

New England Journal of Medicine Oct 20, 2021

Nolan T, Fortanier AC, Leav B, et al. - Healthy children and adolescents developed protection against influenza across seasons after receiving a cell-culture–derived quadrivalent inactivated influenza vaccine (IIV4c), this was observed regardless of previous influenza vaccination.

  • An observer-blinded, randomized clinical trial evaluating IIV4c vs non influenza vaccine (meningococcal ACWY) among 4,514 children and adolescents 2 to less than 18 years of age.

  • Efficacies of 80.7%, 42.1%, and 47.6% were recorded against influenza A/H1N1, influenza A/H3N2 and influenza B, respectively.

  • The IIV4c group and the comparator group had similar incidences of adverse events.

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