Dicko A, et al. - Researchers aimed at determining the efficacy and safety of primaquine and methylene blue in preventing human to mosquito transmission of P falciparum among glucose-6-phosphate dehydrogenase (G6PD)-normal, gametocytaemic male participants. Findings from this phase 2, single-blind, randomised controlled trial performed at the Clinical Research Centre of the Malaria Research and Training Centre (MRTC) of the University of Bamako (Bamako, Mali) demonstrated a high efficacy of adding a single dose of 0·25 mg/kg primaquine to sulfadoxine-pyrimethamine and amodiaquine or 3 days of 15 mg/kg per day methylene blue to dihydroartemisinin-piperaquine for preventing P falciparum transmission. Both primaquine and methylene blue were noted to be well tolerated.