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Efficacy and clinical significance of omitting blue dye injection during sentinel lymph node biopsy before Mohs micrographic surgery for malignant melanoma of the lower extremities

British Journal of Dermatology Aug 01, 2019

Kim TH, et al. - In patients who subsequently underwent Mohs micrographic surgery (MMS) for melanomas of the lower extremities, researchers evaluated the effectiveness of sentinel lymph node biopsy (SLNB) without blue dye injection. Patients who had MMS with or without SLNB were assessed using preoperative localization of the primary melanoma through lymphoscintigraphy and intraoperative confirmation using a gamma probe between 2010 and 2016. For this investigation, 72 patients with melanoma of mean Breslow thickness 3·03 ± 1·44 mm have been assessed. According to findings, 65 of the 72 patients had SLNB, the success rate of which was 98%. The overall 5-year and disease-free survival rates, respectively, were 78% and 76%. Without compromising the accuracy of standard SLNB, blue dye injection can be omitted. Omitting blue dye injection has also highlighted benefits for melanoma in MMS.
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