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Effects of water loading on observed and predicted plasma sodium, and fluid and urine cation excretion in healthy individuals

American Journal of Kidney Diseases Apr 23, 2019

Wouda RD, et al. - In this single-center study of 12 apparently healthy men, researchers performed a water-loading test (20 mL water/kg in 20 minutes) to see if sodium can be released from its nonosmotic stores after a hypotonic fluid load. The participants were observed during a 240-minute follow-up so that the observed plasma sodium concentration ([Na+]) and fluid and urine cation excretion could be compared with values predicted by the Barsoum-Levine and Nguyen-Kurtz formulas. They found mean plasma [Na+] decreased 3.2 ± 1.6 (SD) mmol/L at 30 minutes following water loading, thereafter a gradual increase in plasma [Na+] was observed. A significant underestimation of plasma [Na+] by the Barsoum-Levine and Nguyen-Kurtz formulas was seen at 120 minutes following water loading. According to the findings, mobilization of osmotically inactivated sodium was possible in healthy individuals following an acute hypotonic fluid load.
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