Apaydin T, Polat H, Yazan CD, et al. - In this study, 25 hydroxyvitamin D [25 (OH)D] concentrations were not associated with the severity and mortality of coronavirus disease (COVID-19). Findings demonstrate independent association of vitamin D receptor (VDR) gene polymorphisms with the severity of COVID-19 as well as patient survival.

• In this study of 297 patients with COVID-19, the goal was to assess the link between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID-19 in respect to vitamin D deficiency.

• Of participants, 83% had vitamin D deficiency, and 40.7% had severe deficiency.

• There was no association of vitamin D levels with inflammatory markers, disease severity, admission to ICU, or mortality.

• While disease severity was found to be associated with Fok I Ff genotype, it was Taq TT genotype for ICU admission.

• Those who died commonly had the ApaI aa genotype.

• None of the deceased individuals exhibited the Fok I FF genotype.