de Carvalho Dutra B, et al. - In this randomized split-mouth clinical trial, researchers randomly treated 64 intrabony defects from 32 patients with periodontitis with either 1% sodium alendronate (ALN) gel or placebo gel during periodontal surgeries in order to evaluate the topical application of 1% ALN gel for efficacy. They noted significant improvements in clinical attachment level, probing depth, and bleeding on probing after periodontal surgical procedures in both ALN and placebo groups. The ALN group showed significantly better outcomes with higher PD reduction and clinical attachment gain in intergroup analysis. Digital subtraction radiography indicated positive effects on periodontal bone repair strongly associated in the ALN group. Findings thus suggest that during surgical periodontal therapy, topical application of 1% ALN couls be a promising and beneficial adjuvant for the treatment of intrabony defects.