Bredella MA, Singhal V, Karzar NH, et al. - In the present study, the researchers sought to discover the impacts of sleeve gastrectomy (SG) on volumetric BMD (vBMD) and marrow adipose tissue (MAT) in adolescents with obesity. They speculated that SG will lead to reduced vBMD and differential MAT changes. A 12-month prospective study in 52 adolescents with moderate-to-severe obesity (38F, mean age:17.5 ± 2.2 years, mean BMI:45.2 ± 7.0 kg/m²), 26 individuals before and after SG and 26 nonsurgical controls. According to results, adolescents lost 34.1±13.1 kg after SG compared with 0.3±8.4 kg in the control group. SG in adolescents reduced lumbar vBMD related to an increase in lumbar MAT and a decrease in extremity MAT. This shows differential changes of regulated MAT in the lumbar spine as well as constitutive MAT in the distal skeleton in adolescents in response to SG.