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Effects of prophylactic atropine on the time to tracheal intubation with the pre‐administration of remifentanil

Acta Anaesthesiologica Scandinavica Dec 17, 2020

Shim JG, Cho EA, Ryu KH, et al. - Given that pre‐administration of remifentanil in target‐controlled propofol and remifentanil anaesthesia could result in prolongation of the time of onset of muscle relaxation because of haemodynamic impacts, thereby prolonging the time to tracheal intubation, researchers sought to determine if prophylactic use of atropine could avert the prolongation of the time to tracheal intubation. Participants were 64 patients, who were randomly assigned to Group A (atropine 0.5 mg, n = 32) and Group S (saline 0.9%, n = 32), immediately prior to the pre‐administration of remifentanil. In cases pre‐administered with remifentanil in target‐controlled propofol and remifentanil anaesthesia, atropine could compensate for the decrease in cardiac output when used as a prophylactic. This subsequently resulted in prevention of prolongation of rocuronium onset time as well as decreased the time to tracheal intubation.

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