de Luis DA, et al. - The purpose herein was to gauge the effects of rs3123554 of CB2R receptor gene on metabolic and adiposity parameters following 2 different hypocaloric diets in obese individuals. Less body weight was lost by carriers of the minor allele of rs3123554 variant of CB2R gene during 2 different hypocaloric diets. It was determined that the improvement of metabolic parameters was better in no A allele carriers when compared to A allele carriers.