DeBoer MD, et al. - Researchers determined the impacts of circulating sex hormones [testosterone, dehydroepiandrosterone sulfate (DHEA-S), estrogen, and progesterone] on lung function and symptom control in adolescents with asthma. Using linear regression, the analysis of 187 children 6–18 years of age (59% severe) enrolled in the NIH/NHLBI Severe Asthma Research Program (SARP) revealed beneficial effects of androgens on lung function and symptom control and weak deleterious effects of estradiol on lung function in the examined patient populace.