Harray AJ, Binkowski S, Keating BL, et al. - The effect of fat and protein on postprandial glucose excursions may be mediated by differences in glucoregulatory hormone secretion.

• A total of 21 participants with type 1 diabetes aged 12 to 21 years were studied for ≥ 1 year.

• Meals low in fat and protein had little impact on GLP-1, whereas there was a sustained increase after high protein [HP] (80.3 ± 16.8pmol/L) vs low protein [LP] (56.9 ± 18.6), and high protein/high fat [HPHF] (103.0 ± 26.9) vs low protein/low fat (LPLF] (69.5 ± 31.9) meals.

• The HP (190.2 ± 35.7pmol/L) vs LP (152.3 ± 23.3) and HPHF (258.6 ± 31.0) vs LPLF (151.7 ± 29.4) had a greater immediate rise in glucagon-dependent insulinotropic polypeptide after all meals.

• Glucagon levels increased in response to protein, with HP (292.5 ± 88.1pg/mL) vs LP (182.8 ± 48.5).