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Effects of continuous infusion of phenylephrine vs norepinephrine on parturients and fetuses under lidcorapid monitoring: A randomized, double-blind, placebo-controlled study

BMC Anesthesiology Sep 13, 2020

Feng K, Wang X, Feng X, et al. - Via this prospective, single-center, randomized, controlled study including 238 consecutive term parturients who underwent cesarean delivery (CD), researchers sought to determine how continuous administration of phenylephrine vs norepinephrine during elective CD affects maternal hemodynamic parameters and maternal and fetal outcomes. Participants received either continuous infusion of 0.25 μg/kg/min phenylephrine or 0.05 μg/kg/min norepinephrine, or placebo. Per outcomes, phenylephrine and norepinephrine have similar efficacy in preventing spinal anesthesia (SA)-induced hypotension, with no difference in the incidence of maternal bradycardia. However, phenylephrine, in particular, better preserves the systemic vascular resistance (SVR) by maintaining appropriate cardiac afterload and yielded better neonatal outcomes base on blood gas parameter.

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