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Effects of body mass index on kidney transplant outcomes are significantly modified by patient characteristics

American Journal of Transplantation Aug 31, 2020

Schold JD, Augustine JJ, Huml AM, et al. - Researchers investigated impacts of body mass index (BMI) using survival models as well as examined interactions with recipient characteristics among 296,807 adult (age > 17) solitary kidney transplant recipients from the Scientific Registry of Transplant Recipients (2000‐2019). Experts noted that BMI showed a “J‐Shaped” risk profile with raised risks for overall graft loss with low BMI and obesity. For older recipients (> 60 years), persons with type I diabetes, and men, low BMI was relatively higher risk. High BMI was found to be related to raised risk for Caucasians and decreased risk in African Americans and individuals with type II diabetes. Findings revealed that among kidney transplant recipients, there was a highly variable link of BMI with posttransplant outcomes. Based on these data, it was advised that absolute BMI thresholds should not be the base for transplant contraindications. Instead, modifying transplant contraindications based on patient characteristics was recommended.

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