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Effects of body mass index on kidney transplant outcomes are significantly modified by patient characteristics

American Journal of Transplantation Jul 15, 2020

Schold JD, Augustine JJ, Huml AM, et al. - Given the value of BMI as a risk factor linked with kidney transplant outcomes and its incorporation in determining transplant candidate eligibility, researchers here examined 296,807 adult (age >17) solitary kidney transplant recipients from the SRTR (2000‐2019) and evaluated how BMI affected in these cases using survival models and tested its interactions with recipient characteristics. Overall, a ‘J‐Shaped’ risk profile was observed of BMI, with increased risks for overall graft loss with low BMI and obesity. Multivariable models, however, revealed interactions of BMI with recipient age, diagnosis, gender and race/ethnicity. For older recipients (> 60 years), patients with type‐I diabetes and males, low BMI was relatively higher risk. High BMI was linked with increased risk for Caucasians and reduced risk among African Americans and patients with type‐II diabetes. In competing risks models, effects of BMI had variable risks for mortality vs graft loss by recipient characteristics. They identified highly variable association of BMI with posttransplant outcomes among kidney transplant recipients. Per these findings, they suggest that transplant contraindications should not be based on absolute BMI thresholds, but modified based on patient characteristics.

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