Thomopoulos C, et al. - Via analyzing data on older and younger individuals (cutoffs of 65 [primary analyses], 70, 75, 80, 60 and 55 years) from 72 blood pressure (BP)-lowering randomized controlled trials (RCTs) including 260,210 patients, researchers investigated the following clinically relevant issues concerning the effects of BP lowering in these patients: differences in benefits, the oldest and the youngest age range for which evidence of BP-lowering effects is available, the SBP level at which BP-lowering treatment should be initiated, the SBP and DBP levels treatment should be aimed at, and differences in treatment burdens and harms. As per results, researchers recommended antihypertensive treatment to all individuals with elevated BP, independent of age. Initiation of treatment at SBP values 140–159 mmHg is supported at older age (≥ 60 years). Until age 80 years, incremental benefits without disproportionate burdens were achieved with SBP and DBP values lower than 140 mmHg and 80 mmHg, respectively.