Park JW, et al. - Researchers examined how perioperative use of angiotensin receptor blocker (ARB: a commonly used antihypertensive drug) influenced the outcomes of patients who underwent immediate breast reconstruction using a tissue expander or a deep inferior epigastric perforator (DIEP) flap. Analyzing 1,390 cases, including 999 cases of tissue-expander insertion and 391 cases of DIEP flap reconstruction, they identified the possibility of adverse outcomes after breast reconstruction in correlation to the perioperative administration of ARB. The rates of seroma, reoperation, reconstruction failure, and overall complications were significantly higher in the ARB group than in the other two groups regarding tissue-expander reconstruction. The ARB group showed a significantly increased rate of fat necrosis and significantly higher odds of perfusion-related complications and fat necrosis vs the control group regarding DIEP flap reconstruction, after adjustment for other variables.