Bugada D, et al. - Persistent postsurgical pain (PPSP) and long-term postoperative functional outcome were assessed in patients who received regional anaesthesia for total knee arthroplasty (TKA). The analgesic benefit of continuous regional anaesthesia was evident up to 1-month post- surgery, with no reported impact on PPSP at 6 months. In addition, better pain control at 1 month was found to be associated with reduced PPSP. PPSP was more likely in patients with higher expectations from surgery, enhanced basal inflammation and a pessimistic outlook.