Kurosaki Y, et al. - In the present study, the researchers sought to examine the impacts of 308 nm excimer light treatment on the skin bacterial and fungal microbiome of the lesional skin of atopic dermatitis (AD) patients by contrasting it with that of non-lesional skin and healthy controls (HC). Swab samples were obtained from 11 HC, non-lesional and lesional skin of 11 AD individuals at the outpatient clinic of the Department of Dermatology, Juntendo University Urayasu Hospital, Japan. Findings suggested that 308 nm excimer light treatment significantly altered bacterial microbiome composition in the lesional skin of AD and improved the clinical results. The data presented in this work showed a significant link between the reduction of Staphylococcus aureus (S aureus) and improvement of the clinical outcomes. The findings suggest that alterations in the skin microbiome with excimer light treatment, specifically the reduction in S aureus abundance, are partly involved in improving AD lesions.