Carter SG, et al. - Researchers investigated how obstructive sleep apnea (OSA) severity, sleepiness and alertness was impacted by treatment with zopiclone for 1 month in patients with low-moderate respiratory arousal thresholds without major overnight hypoxemia. This is the first study to evaluate the effect of a hypnotic on OSA severity and sleepiness beyond single-night studies. Findings revealed no worsening of OSA severity, sleepiness or alertness as a result of 1 month of zopiclone treatment in selected patients without major overnight hypoxemia. These results yield important safety data and insight into OSA pathophysiology.