Ohki T, Satov K, Kondo M, et al. - Researchers investigated if administration of direct acting antiviral agents (DAAs) induces a favorable effect on hepatocellular carcinoma (HCC) patients with multiple courses of recurrence. A total of 146 HCV related HCC (C-HCC) patients were retrospectively retrieved who received curative treatment using radiofrequency ablation (RFA) followed by eradication treatment with DAA. In addition, 184 C-HCC patients were extracted who were curatively treated using RFA without HCV eradication treatment as controls. Performing propensity score matching, 47 C-HCC patients with eradication of HCV, and 47 C-HCC patients without HCV eradication as controls were finally included. In multivariate analysis, eradication with DAAs, and frequency of recurrence times were identified as independent factors linked to overall survival. Eradication of HCV using DAAs resulted in prolongation of time to curative treatment failure as well as overall survival; this was observed even in C-HCC patients with multiple courses of recurrence.