Li Y, et al. - In this systematic review and meta-analysis involving 247 candidates, researchers compared the efficacy (bracket placement accuracy), efficiency (total working time and chairside time) and adverse effects (oral hygiene status and bond failure rate) of direct and indirect bonding techniques in orthodontic patients. Weak evidence suggested that the techniques of direct and indirect bonding for bonding orthodontic brackets did not significantly differ in bracket placement accuracy, oral hygiene status, and bond failure rate. Indirect bonding may require less chairside time but more total working time compared to the technique of direct bonding. To create a conclusive suggestion, high-quality and well-designed randomized controlled trials are required.