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Effective treatment of cutaneous mold infections by antimicrobial blue light that is potentiated by quinine

The Journal of Infectious Diseases Feb 06, 2021

Leanse LG, dos Anjos C, Wang Y, et al. - Researchers conducted the study for analyzing the use of antimicrobial blue light (aBL; 405 nm wavelength) and the combination of aBL with quinine hydrochloride (aBL + Q-HCL) for the treatment of cutaneous mold infections. They investigated the efficacy of aBL and aBL + Q-HCL in killing clinically important pathogenic molds (Aspergillus fumigatus, Aspergillus flavus, and Fusarium oxyprorum). Findings suggested that mold conidia are tolerant to aBL, but Q-HCL improves efficacy. aBL and aBL + Q-HCL effectively decreased the burden of A. fumigatus within an established dermabrasion infection that restricted recurrence posttreatment. For the treatment of mold infections, aBL and aBL + Q-HCL can offer a novel approach.

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