Rosser FJ, Han YY, Forno E, et al. - Among children suffering from asthma and having low vitamin D levels, it was investigated if vitamin D supplementation could decrease the levels of total IgE (immunoglobulin E), and IgE to each of two common indoor allergens. A total of 174 participants in a multicenter, double-blind, randomized placebo-controlled trial [Vitamin D Kids Asthma study (VDKA)] of vitamin D ₃ supplementation (4,000 IU/day) to avert severe exacerbations in children experiencing persistent asthma and having vitamin D levels <30 ng/ml, were analyzed. In these participants, total IgE, IgE to Dermatophagoides pteronyssinus, and IgE to Blattella germanica were recorded at the randomization and exit visits. Findings showed no significant impact of vitamin D supplementation, vs placebo, on serum concentrations of total IgE, IgE to dust mite, or IgE to cockroach among children with asthma and low vitamin D levels.