Angellotti E, et al. - In patients with well-controlled type 2 diabetes, researchers assessed the impact of oral daily vitamin D supplementation on lipid profile and cardiovascular disease (CVD) risk. For this investigation, 127 subjects (mean age 60 years) with stable (HbA1c ≤ 7.5%) diabetes managed with lifestyle only or lifestyle plus metformin were randomly allocated to receive either 4,000 IU/day of vitamin D₃ (n = 66) or placebo (n = 61) for 48 weeks. In patients with stable type 2 diabetes not selected for vitamin D deficiency, one-year supplementation with vitamin D₃ at 4,000 IU/day had no affect on lipid profile, C-reactive protein or CVD risk. Vitamin D supplementation reduced triglycerides (TG) vs placebo at week 48 among patients who were not on cholesterol medication.