Zampieri FG, Machado FR, Biondi RS, et al. - No reduction in 90-day mortality was observed among critically ill patients requiring fluid challenges in correlation with lower intravenous fluid infusion rates compared with a faster rate.

• Unblinded randomized factorial clinical trial, involving 10,520 patients in intensive care units.

• Ninety-day mortality of 26.6% vs 27.0% was recorded in correlation with undergoing treatment with fluid boluses at 333 mL/h vs 999 mL/h, indicating no statistically significant difference in terms of 90-day mortality .