van der Stuijt W, et al. - Among healthy subjects (n=432, mean age 28.5 ± 12.5; 88.9% male) who participated in early drug development studies, researchers compared the impacts of fasting on standard 12-lead electrocardiographic recordings to determine if electrocardiographic parameters are influenced by length of fasting. As part of the drug development studies, participants had electrocardiograms (ECGs) available for after 4- and 10-hour fasting. Automatic analysis of all ECGs was carried out for conduction intervals and wave amplitudes with the Marquette 12SL algorithm. Changes to the surface ECG (ie a reduced wave amplitude and duration and increased isoelectric interval duration) were evident in relation to 10-hour fasting vs 4-hour fasting in this study.