Ashour ASA, Nabil H, Yosif MF, et al. - Researchers conducted a randomized, double-blinded, placebo-controlled trial investigating efficacy and safety of self-administered 3 mg dinoprostone vaginally in decreasing pain during copper intrauterine device (IUD) insertion in parous women. They randomly assigned 160 multiparous women, who were attending a family planning clinic and requesting copper IUD insertion, into two groups: the dinoprostone group (n = 80) received 3 mg dinoprostone vaginally, and the placebo group (n = 80) received placebo vaginally. Findings revealed reduced pain scores during IUD insertion in correlation with self-administered 3 mg dinoprostone vaginally before copper IUD insertion in parous women; this made insertion easier and increased women’s satisfaction, with tolerable side-effects.