Suhitharan T, et al. - In adult participants with American Society of Anesthesiologists (ASA) status I to III who received general anesthesia for approximately 2 hours when undergoing head and neck surgeries, researchers assessed the occurrence of opioid tolerance and other adverse effects due to remifentanil. Two groups of patients were formed, with one receiving remifentanil infusion and another receiving intermittent boluses of morphine or fentanyl. In post-anesthesia care unit (PACU), intermittent boluses of morphine and fentanyl were used to treat postoperative pain and to achieve a numerical rating scale score of 3. Findings suggested an increase in opioid consumption in the immediate postoperative period after intraoperative remifentanil infusion at clinically relevant doses. For patients undergoing elective head and neck procedures, this could delay discharge from PACU.