Myrberg T, et al. - Whether the use of a preoperative volume bolus based on lean body weight is associated with a reduction in the incidence of significant blood pressure drops (BPD) following induction with target-controlled infusion (TCI) or rapid sequence induction (RSI) was investigated in this study performed on 80 people scheduled for non-cardiac surgery. The participants were randomly assigned to receive either a preoperative colloid fluid bolus of 6 ml kg⁻¹ lean body weight or no bolus, and then anesthetized using TCI or RSI. During the first 20 minutes post-anesthesia induction, blood pressure drops below the mean arterial pressure 65 mm Hg was considered as the main outcome measure. In this study, a reduction in the incidence of significant BPD during TCI and RSI induction of general anesthesia was achieved with the administration of preoperative fluid bolus.