Le May M, Osborne C, Russo J, et al. - Researchers investigated the effect of moderate (target temperature of 31 °C) vs mild hypothermia (target temperature of 34 °C) on the rate of death or poor neurologic outcome in comatose survivors of out-of-hospital cardiac arrest.

• Single-center, double-blind, randomized, clinical superiority trial including 367 adults with out-of-hospital cardiac arrest.

• Patients randomized to receive hypothermia treatment at 31 °C vs 34 °C had 180-day all-cause mortality or poor neurologic outcome of 48.4% vs 45.4%, respectively; no statistically significant value of this difference was evident.

• Overall there appeared no significant reduction in the rate of death or poor neurologic outcome among comatose survivors of out-of-hospital cardiac arrest at 180 days in correlation with a target temperature of 31 °C vs 34 °C.