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Effect of low-dose vs standard-dose valganciclovir in the prevention of cytomegalovirus disease in kidney transplantation recipients: A systemic review and meta-analysis

Transplantation Proceedings Jun 07, 2018

Hwang SD, et al. - The appropriate dose of valganciclovir required to prevent cytomegalovirus (CMV) infection was investigated via performing a systematic review and meta-analysis. Researchers searched the Cochrane Central Register, MEDLINE, EMBASE, and PubMed databases up to April 15, 2017, and identified 450-mg dose of valganciclovir as effective in preventing post-transplantation CMV infection and decreasing drug-induced side effects such as leukopenia. Findings thus suggested this lower dose to have the potential to prevent cytomegalovirus infection and enhance the cost-effectiveness.
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