Vallentin MF, Granfeldt A, Meilandt C, et al. - Via performing a randomized clinical trial, researchers herein examined if administration of calcium during out-of-hospital cardiac arrest aids in improving sustained return of spontaneous circulation in adults.

• A total of 391 adults with out-of-hospital cardiac arrest were included.

• Participants received up to 2 intravenous or intraosseous doses with 5 mmol of calcium chloride (n = 197) or saline (n = 200).

• Administration of the first dose was done immediately following the first dose of epinephrine.

• Sustained return of spontaneous circulation was achieved in 19% of patients receiving treatment with intravenous or intraosseous calcium compared with 27% of those receiving saline; this difference was not statistically significant.

• Early termination of the trial was done due to concerns about harm in the calcium group.