Fraticelli F, et al. - Researchers performed an open-label, parallel, randomized controlled trial comparing the impact of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in gestational diabetes mellitus (GDM) women. For this investigation, members were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg d-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27.6 mg myo/d-chiro-inositol plus 400 mcg folic acid (MI plus DCI treatment). The findings of this study contributed interesting however preliminary results about the potential role of inositol stereoisomers supplementation in the treatment of GDM on insulin resistance levels and several maternal-fetal outcomes.