Yamamoto K, Matsumura‐Nakano Y, Shiomi H, et al. - A significant interaction exists between heart failure and the mortality risk of percutaneous coronary intervention (PCI) when compared with coronary artery bypass grafting (CABG).

• Study population comprised 3,380 patients with three‐vessel or left main coronary artery disease; 827 patients with heart failure (PCI: N = 511, and CABG: N = 316), and 2,553 patients without heart failure (PCI: N = 1619, and CABG: N = 934).

• In the PCI group, patients with heart failure more often had advanced age, severe frailty, acute and severe heart failure, and elevated inflammatory markers.

• Patients with heart failure are at excess risk and patients without heart failure are at neutral risk.