Daghlas I, et al. - Using two-sample Mendelian randomization, researchers studied potential causality between genetically instrumented liability to migraine and cardiovascular disease outcomes. The exposure included 35 independent, genome-wide significant genetic variants identified in the largest published migraine GWAS (N_cases= 59,674 / N_controls = 316,078). The outcome datasets involved GWAS of coronary artery disease [CAD] (76,014 / 264,785), myocardial infarction [MI] (43,676 / 128,199), angina (10,618 / 326,065), and atrial fibrillation [AF] (60,620 / 970,216). According to results, evidence was found for a protective effect of migraine liability on CAD, MI, and angina, but not on AF. Migraine subtype analyses showed an effect of non-aura migraine on CAD risk, but not on aura migraine. Sensitivity analyses showed minimal bias by horizontal pleiotropy, outliers, reverse causality, or sample overlap. A potentially protective effect of genetically instrumented liability to a migraine on CAD risk was identified in this analysis. Mechanistic research is warranted to investigate this link.