Qadri AH, Sproule S, Girling L, et al. - Night-time surgeries are associated with challenges, such as, physician fatigue and sleep deprivation, and fewer staff and resources, compared with daytime surgery, which might contribute to medical errors and complications, and, hence, worse patient outcomes. Researchers conducted this single center retrospective study of 304 patients who underwent emergent neurosurgical procedures including 2 groups based on the timing of surgery: daytime (7:00 am to 6:59 pm) and night-time (7:00 pm to 6:59 am) surgery groups. Outcome analysis suggests that although the groups did not differ significantly in the rate of unfavorable neurological outcome at hospital discharge and 1 month postdischarge, there was a higher proportion of patients in the night-time surgical group with unfavorable neurological outcome (Glasgow Outcome Score 1 to 3) at both these times. The 2 groups showed differences in hospital length of stay, location of postoperative management (postanesthesia care unit or intensive care unit), midline shift, baseline Glasgow Coma Scale score, and acuity of surgery. The possibility of an association between timing of surgery and outcome can not be excluded in light of findings from this study given its limitations, including small sample size and omission of potentially confounding variables.