Sadeghdoust M, Mirsadraee M, Aligolighasemabadi F, et al. - Researchers undertook this randomized, double-blind, placebo-controlled clinical trial to determine how long-term treatment with azithromycin could impact airways wall thickness in patients suffering from severe persistent asthma. Patients were administered azithromycin (250mg, BID (twice a day), three days a week), prednisolone (5mg, BID), or placebo for eight months in three separate groups in addition to the standard therapy. The primary outcome was improvement in right upper lobe apical segmental bronchus wall thickness determined by high resolution computed tomography. Findings revealed that increased lumen radius and lumen area resulted from long-term treatment with azithromycin in patients with severe persistent asthma. However, wall thickness did not alter significantly in any of the treatment groups.