Anis HK, et al. - A sum of 12,541 cases were evaluated to quantify the consequence of commercially available antibiotic-impregnated bone cement (AIBC) on prosthetic joint infections (PJIs), and surgical site infections (SSIs) following primary total knee arthroplasty (TKA). They observed higher PJI rates in the AIBC cohort (1.0%) when compared to the non-AIBC cohort (0.5%). In the AIBC cohort, higher PJI rates were also noted in high-risk patients (1.9% vs 0.6%). They did not record any significant association between PJIs and AIBC use, after adjusting for potential confounders. In a similar manner, they did not report significant differences in SSI rates between the AIBC (2.9%) and non-AIBC cohorts (2.4%). No significant associations were noticed between SSIs and AIBC with multivariate analysis.