Tiong MK, Krishnasamy R, Smith ER, et al. - Given that an opportunity to evaluate the impact of medium cut‐off (MCO) dialyzers on protein‐bound uremic toxins and novel markers of mineral metabolism is offered by the REMOVAL‐HD [tRial Evaluating Mid cut‐Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients], researchers assessed alterations in protein‐bound solutes (total and free indoxyl sulfate and p‐cresyl sulfate) as well as mineral metabolism markers (intact fibroblast growth factor‐23 [iFGF23], fetuin‐A and endogenous calciprotein particles) in this exploratory sub‐study of REMOVAL‐HD. According to findings, a sustained decrease in FGF23 was observed in relation to use of a MCO dialyzer over 24 weeks, while there was no significant change in other measured components of the uremic milieu. There is a need for further investigations to ascertain if FGF23 decrease is related to improved patient outcomes.