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Early-stage predictors for treatment responses in patients with active lupus nephritis

Lupus Feb 01, 2019

Liu G, et al. - In this retrospective study, researchers have analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission. Study participants included 64 LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than 6 months. They used receiver operating characteristic curves to test the predictive values of urinary protein-to-creatinine ratio (UPCR), serum albumin and complement C3 at the first, second and third months as predictors for remission at the sixth month. For anticipating remission at the sixth month in LN, the change percentage of UPCR ≥59% and the serum albumin ≥32.9 g/l at the third month were valuable. The cutoff value of the change percentage of UPCR at month 3 was 59% and the cutoff value of serum albumin at month 3 was 32.9g/l.
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