Bressler NM, et al. - After 12 weeks of anti-vascular endothelial growth factor treatment for diabetic macular edema in DRCR.net Protocol T, researchers evaluated the correlations of 2-year visual acuity (VA) outcomes with VA and optical coherence tomography central subfield thickness (CST). Meaningful vision improvement (ie, ≥ 10-letter gain) in many eyes at 2 years could not be written off, even with suboptimal response at 12 weeks. Often a good VA at 2 years was seen in eyes with less than a 5-letter gain at 12 weeks without switching therapies.