Early prediction of decompensation (EPOD) score: Non-invasive determination of cirrhosis decompensation risk
Liver International Feb 05, 2022
This study affords a prediction tool, the Early Prediction of Decompensation (EPOD) score, for the risk of decompensation in patients with cirrhosis. This score demonstrated better performance than well-known cirrhosis scores. Because EPOD is based on three blood parameters, only, it offers maximal clinical feasibility at minimal costs.
This study included 6,049 cirrhosis patients in the IBM Explorys database training cohort as well as the IBM Explorys database validation cohort (N = 17,662), the Penn Medicine BioBank (N = 1,326) and the UK Biobank (N = 317).
The new EPOD score uses platelet count, albumin, and bilirubin level.
This score enabled decompensation prediction during a 3-year follow-up in three validation cohorts with areas under the receiver operating characteristic of 0.69, 0.69 and 0.77, respectively, and displayed superior performance than the well-known MELD and Child-Pugh score in predicting decompensation.
Furthermore, prediction of the 3-year likelihood of decompensation was achieved with the EPOD score.
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