Jin J, et al. - Via retrospective analyses performed in this single-center study, researchers investigated whether a small increase of early postoperative serum creatinine (SCr) adjusted for fluid balance had superior discrimination ability in subsequent acute kidney injury (AKI) prediction. This study was performed on adult patients (n=1,016) who had elective isolated or combined valve surgery in 2015. AKI development was reported in 355 patients (34.9%). Factors that showed independent associations with the development of AKI were age, weight, European System for Cardiac Operative Risk Evaluation II, and cardiopulmonary bypass duration, as revealed in multivariate logistic analyses. In valve surgery patients, the predictive ability for subsequent development of AKI could be improved by early fluid-adjusted relative changes of SCr.