Rong D, et al. - In non-small-cell lung cancer (NSCLC) patients with bone metastases (BM), experts assessed the connection between osteosclerotic changes and chemotherapy response by analyzing data of 52 NSCLC patients with BM from January 1, 2010, to June 31, 2015. In NSCLC patients with BM, early osteosclerotic changes forecast chemotherapy response. Univariate Cox regression analysis showed that pathological subtype and osteosclerotic changes were significant predictors of progression-free survival (PFS).