Early markers of periodontal disease and altered oral microbiota are associated with glycemic control in children with type 1 diabetes
Pediatric Diabetes Apr 12, 2021
Jensen ED, Selway CA, Allen G, et al. - In this cross‐sectional study, researchers determined the connection between periodontal disease and glycemic control in children with type 1 diabetes and characterized the diversity and composition of their oral microbiota. The sample consisted of children with type 1 diabetes recruited from clinics at the Women's and Children's Hospital (Australia). Seventy‐seven candidates (age 13.3 ± 2.6 years, 38 males, BMI z‐score 0.81 ± 0.75) had a diabetes duration of 5.6 ± 3.9 years and median HbA1c of 8.5% (range 5.8–13.3), 69.4 mmol/mol (range 39.9–121.9). HbA1c was positively associated with plaque index, gingival index, bleeding on probing and periodontal pocket depth > 3 mm. Brushing frequency, plaque index, and gingival index all had an impact on microbiota composition, regardless of HbA1c. Children with type 1 diabetes had a consistent relationship between poor glycemic control and higher levels of early periodontal disease markers. The complexity and richness of the plaque microbiota were also related to glycemic control, with diversity increasing as HbA1c levels increased.
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