Jensen ET, et al. - In this study, gene-environment interaction was tested between eosinophilic esophagitis (EoE)-predisposing polymorphisms (within TSLP, LOC283710/KLF13, CAPN14, CCL26, and TGFB) and implicated early-life factors (antibiotic use in infancy, cesarean delivery, breast-feeding, neonatal intensive care unit [NICU] admission, and absence of pets in the home). Findings illustrated a possible contribution of the interplay of gene (CAPN14 and LOC283710/KLF13) and early-life environment factors (breast-feeding and NICU admission) to EoE susceptibility.