Logan K, Perkin MR, Marrs T, et al. - In this prespecified analysis of a randomized clinical trial, experts explored if early introduction of high-dose gluten can reduce the prevalence of celiac disease (CD) at age 3 years. In total, 1,303 children from the general population in England and Wales were selected and followed up from November 2, 2009, to July 30, 2012. They randomized infants to eat six allergenic foods (peanut, sesame, hen's egg, cow's milk, cod fish, and wheat) plus breast milk starting at 4-months-old (early introduction group) or to avoid allergenic foods and follow UK infant feeding recommendations of only breastfeeding until around 6 months of age (standard introduction group). Of the 1,004 infants involved in the analysis, 514 were male (51.2%).  Lower prevalence of CD was linked to the introduction of gluten from age 4 months in this analysis. In future research, early high-dose gluten intake should be considered as a preventive strategy for CD.